Nanoparticles Created to Enter Individual Cells

Good ‘ol MIT isn’t just charting new ground in Plasma Fusion technologies and Artificial Intelligence – now they’ve developed a nanoparticle that can penetrate our cells and do things once inside.

Dr. Ram Sasisekharan is the project lead at MIT’s Biological Engineering Division for what has been coined their anti-cancer smart bomb.

Apparently, this nanoparticle is actually proving to be quite an effective lung and melanoma cancer treatment, greatly increasing the survival rates in mice and also greatly minimizing the collateral damage normally unleashed with traditional chemotherapy techniques.

This comes at a good time for me – a man who for several years meant the world to me was recently diagnosed with lung cancer. I think he is probably the most active person I’ve known, too. My sister is an oncology nurse, so I have a good understanding of what people actually go through – and this news is most welcome and celebrated, though the ramifications are staggering.

This little nanoparticle has a “stealth” outer surface chemistry that allows them to evade the immune system, and their size of 200 nanometers apparently makes them the perfect size for absorbtion into tumors.

More genius comes from their dual-chamber interior which first releases an anti-angiogenic drug which causes the blood vessels feeding the tumour to collapse and trap the particle inside the tumour and starving the tumour.

In addition to this wonderful turn of events, its second chamber releases a chemotherapy agent that works to destroy the tumor as well. This occurs very quickly it seems.

Of all the treatments tested on mice, the nanoparticle shrank the tumor better, stopped angiogenesis and released far less toxins into the system.

It’s a brilliant delivery system, I think – something that is so much better than flooding our bodies with chemicals. Highly specific.

Heidi — you’re the medical maven in my life — do you have any information about this sorta thang? I don’t expect a medical education, so don’t go getting all despairing of having to write too much information down… I’m just really curious — and would love to know anything you might think could enlighten me a little…

And how can humans get in these experiments — if they start having them? I hate the thought of Marc being flooding with toxic chemotherapy and burned with radiation. I rather see him, if he’s going to go out, leave and advance a science than just wither away, destoyed by both the disease and the treatment.

Oh, the results: 80% of the mice treated with the nanocells survived beyond 65 days. Only 30% survived with the best current therapy. And of mice left untreated – 20% survived.

Ugh. I should stop smoking. Damnit.